Upon release, Lost Highway received mixed reviews and grossed $3.7 million in North America after a modest three-week run. The film's soundtrack, which was produced by Trent Reznor, features an original score by Angelo Badalamenti and Barry Adamson, as well as contributions from artists including David Bowie, Marilyn Manson, Rammstein, Nine Inch Nails and The Smashing Pumpkins. The film's surreal narrative structure has been likened to a Möbius strip, while Lynch has described it as a ' psychogenic fugue' rather than a conventionally logical story.

Lost Highway was financed by the French production company Ciby 2000 and was largely shot in Los Angeles, where Lynch collaborated with frequent producer Mary Sweeney and cinematographer Peter Deming. He is suddenly convicted of murder, after which he inexplicably disappears and is replaced by a young mechanic (Getty) leading a different life. The film follows a musician (Pullman) who begins receiving mysterious messages and VHS tapes of him and his wife (Arquette) in their home. It stars Bill Pullman, Patricia Arquette, Balthazar Getty, and Robert Blake. Lost Highway is a 1997 neo-noir film directed by David Lynch and co-written by Lynch and Barry Gifford.

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